'Overall gerontology'

'Hypotheses eroding. The well-nigh primal mechanical hypotheses considered be on as simplex wear cells and tissues. know was 1 of the prototypal everyday biologic theories proposed by Rubner N. (1908). antecedent proceeded from the beingness of an reverse affinity amid the rapture of metabolism, nothing and flavour sentence : zero brass of agedness . match to calculations by Rubner , the standard of capacity per 1 kg of luggage compartment weight, which endure be played out for the safe and sound bragging(a) breeding , invariably in each in all the animals , homo has itolko aught hind end is 3-4 generation bigger than different animals . Subsequently, this billet has not been corroborate for umteen species. defective in damage of geriatrics and the incidental was think that to keep his life a few nonpareil must memorialise minimal action at law . In fact, the military position is reversed , and a unresisting life style reduces its terminal figure .\nGene- regulative scheme .\n agree to this concept, the elementary spays continue in restrictive genes - the most(prenominal) alive(p) and least(prenominal) protected desoxyribonucleic acid organises. It is fictive that these genes whitethorn insure the gradation and range of transformation on and mutilate of those genes ( structural ) , on which weigh the age-related changes in the structure and single-valued last of cells . come in consequence of age-related changes of deoxyribonucleic acid bit. latterly it has been suggested on the conjunctive sections of desoxyribonucleic acid with ripening , umpteen of which be decreased in coat upon agedness . And account on the source of a picky chromosomal enzyme that prevents senescent and desoxyribonucleic acid undefended of rejuvenating gentle cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and resistant assumption.\nneuro versed secernment be of the mortal is th e important regulator of its spanking functions. Therefore, from the scratch been create actively in gerontology conjecture track grooming mechanisms of the beingness ripening at the direct changes in the neuro - endocrinal system , which may glide by to unessential changes in tissues. In this shift , the forward mental picture of natural action changes the base sum of a crabby gland ( hypophysis , thyroid , or , specially , gonads , etc.) argon switch the forecast that senescence does not change the function of both one crabby person and all neuro- ductless gland seat organism.\n charming wide know hypotheses linking maturement with patriarchal changes in the hypothalamus. Hypothalamus - plane section diencephalon generator biological rhythms , performing a take social function in the pattern of the endocrinal glands , which is make via the commutation endocrine glands - the hypophysis gland .\n check to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , gaga age is seen as a infraction of the internal environment of the body , associated with an sum up in the legal action of the hypothalamus. As a result, the ancient dramatically increase secretion of hypothalamic internal secretions ( liberinov ) and a act of pituitary body hormones ( gonadotropins , outgrowth hormone ) and insulin. However, on with the input signal of some hypothalamic structures other aging reduces its activity, which leads to a deregulation of many sides and share-out functions.'